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Lipase
Lipase is the specific enzyme measured in this test. Produced by the pancreas, lipase plays a key role in digesting fats by breaking down triglycerides into free fatty acids and glycerol. In healthy individuals, only small amounts of lipase circulate in the blood. However, when the pancreas is damaged or inflamed — such as in acute pancreatitis — lipase can leak into the bloodstream, leading to a marked rise in blood levels. A significantly elevated lipase level is one of the most sensitive and specific indicators of pancreatic inflammation. It typically rises within hours of an acute episode, peaks around 24–48 hours, and may remain elevated for several days. This makes it especially useful in diagnosing and monitoring pancreatitis or assessing whether abdominal pain is likely due to a pancreatic cause. Lower-than-normal lipase levels are less common but may be seen in individuals with chronic pancreatic insufficiency, where the pancreas loses its ability to produce digestive enzymes over time. This may occur in long-term alcohol abuse, cystic fibrosis, or advanced pancreatic disease.