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Iron
Iron is essential for the production of haemoglobin, which carries oxygen in the blood. Low iron levels can lead to iron deficiency anaemia, one of the most common causes of chronic fatigue, weakness, and poor exercise tolerance. Even mildly reduced iron stores can affect concentration, mood, and energy.

Thyroxine (T4)
Thyroxine is a key hormone produced by the thyroid gland that regulates metabolism and energy use. Low levels of T4 can suggest hypothyroidism, a condition often associated with fatigue, weight gain, and low mood. T4 is often measured alongside TSH to get a full picture of thyroid health.

Thyroid Stimulating Hormone (TSH)
Thyroid Stimulating Hormone is produced by the pituitary gland and regulates the thyroid’s hormone output. High TSH levels typically indicate an underactive thyroid (hypothyroidism), which slows down metabolism and can result in tiredness, cold intolerance, and depression. Low TSH may point to an overactive thyroid (hyperthyroidism), which can also disrupt energy balance.

Vitamin D
Vitamin D is crucial for muscle strength, immune health, and energy regulation. Deficiency is common, especially in winter months or in people with limited sun exposure. Low vitamin D levels have been associated with fatigue, muscle aches, low mood, and impaired immunity.

Free Triiodothyronine (FT3)
Free Triiodothyronine is the active form of thyroid hormone that directly affects metabolic rate and energy levels. While T4 is a storage hormone, FT3 is what the body uses to fuel cellular processes. Abnormal FT3 levels can signal thyroid conversion issues or deeper thyroid imbalance, especially when TSH or T4 results are borderline.

hs-CRP (high sensitivity C-Reactive Protein)
hs-CRP is a sensitive marker of low-grade inflammation, which has been linked to chronic fatigue, particularly in conditions like autoimmune disease or post-viral syndromes. Elevated hs-CRP may indicate that inflammation is contributing to your fatigue, even if other symptoms are mild.