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DHEA-Sulphate (DHEA-S)
DHEA-Sulphate is the sulphated form of dehydroepiandrosterone, a steroid hormone produced mainly by the adrenal cortex. Unlike DHEA, which fluctuates throughout the day, DHEA-S has a longer half-life and more stable blood levels, making it a reliable marker for adrenal androgen production. DHEA-S serves as a precursor that the body converts into androgens and oestrogens, hormones essential for sexual development and reproductive function. Elevated DHEA-S levels can signal conditions such as adrenal hyperplasia, adrenal tumours, or PCOS, often linked to symptoms like excess hair growth (hirsutism), acne, or irregular menstrual cycles in women. Conversely, low levels might indicate adrenal insufficiency or hypopituitarism, which can lead to fatigue, low libido, and other hormonal deficiencies. Since DHEA-S reflects adrenal health and androgen production, it is routinely included in panels investigating unexplained hormonal symptoms, fertility concerns, and adrenal disorders. This biomarker plays a crucial role in understanding your body’s hormone balance and guiding appropriate treatment or further investigation.