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Globulin and Total Protein
These proteins are measured to evaluate immune health, liver function, and nutritional status. Globulin includes transport proteins and antibodies that support immune function, while total protein reflects the overall protein balance in the bloodstream. Abnormal values can indicate chronic inflammation, liver or kidney disease, or protein malnutrition—factors that can affect energy, immunity, and systemic wellbeing.

Gamma-Glutamyltransferase (GGT) and Alkaline Phosphatase (ALP)
GGT and ALP are enzymes linked to liver and bile duct function. Raised GGT levels may point to liver stress, often from alcohol use or medications, while ALP may be elevated in bile obstruction or bone disorders. When both are elevated together, it may suggest cholestasis or hepatobiliary disease. These markers help detect liver damage even before symptoms arise.

Triglycerides, HDL % of Total, Non-HDL Cholesterol, Total Cholesterol, HDL Cholesterol, and LDL Cholesterol
This full lipid profile is essential for understanding cardiovascular health. Total cholesterol reflects all cholesterol types, while LDL is considered the “bad” cholesterol that contributes to arterial plaque. HDL, the “good” cholesterol, helps remove excess cholesterol. Non-HDL cholesterol is a broader risk marker, including all atherogenic particles. Triglycerides indicate fat metabolism and are closely linked to insulin resistance. HDL % of total shows the proportion of protective cholesterol. Abnormal lipid levels are strongly linked to heart disease and stroke risk, making this profile a key part of preventative health screening.

Creatinine, Urea, and Estimated Glomerular Filtration Rate (eGFR)
These three biomarkers assess kidney filtration and waste clearance. Creatinine is a waste product from muscle metabolism, and urea results from protein breakdown—both are excreted via the kidneys. eGFR is calculated to estimate your kidney function. Reduced filtration capacity can indicate chronic kidney disease or early-stage renal dysfunction, which is especially important in people with high blood pressure or diabetes.

HbA1c (Glycated Haemoglobin)
HbA1c reflects your average blood glucose over the previous two to three months. Elevated HbA1c is used to diagnose and monitor type 2 diabetes, while borderline levels may indicate prediabetes or metabolic syndrome. Long-term elevated blood sugar increases the risk of cardiovascular disease, nerve damage, kidney disease, and other complications. This marker is essential for anyone concerned about energy, fatigue, or blood sugar stability.

TIBC, Transferrin Saturation, Iron, UIBC, and Ferritin
This comprehensive iron panel evaluates how well your body absorbs, transports, and stores iron. Iron measures circulating iron, while UIBC and TIBC reflect how much more iron your blood can carry. Transferrin saturation calculates the percentage of transferrin that is bound to iron. Ferritin is your main iron storage protein. Low ferritin may indicate iron deficiency—even in the absence of anaemia—while high ferritin could reflect inflammation or iron overload. This panel is crucial in evaluating fatigue, weakness, and anaemia risk.

Uric Acid
Uric acid is a by-product of purine metabolism and is normally excreted by the kidneys. Elevated levels can lead to gout, joint pain, or kidney stones, and are also associated with metabolic syndrome and cardiovascular risk. Monitoring uric acid is important for those with joint pain, high meat or alcohol intake, or a family history of gout or kidney disease.

Vitamin B12 Active, Vitamin D, and Folate
These are three of the most important micronutrients for energy, cognitive function, immunity, and cellular repair. Active B12 (holotranscobalamin) is the form of B12 your body can use, making it a more accurate measure of functional B12 status. Vitamin D is essential for bone health, hormone balance, and immune regulation—deficiency is common in the UK. Folate (vitamin B9) is necessary for DNA synthesis and red blood cell production, particularly important during pregnancy. Low levels of any of these can result in fatigue, low mood, poor concentration, or anaemia.

hs-CRP (High-Sensitivity C-Reactive Protein)
This sensitive marker detects chronic low-grade inflammation, which may go unnoticed but contributes to conditions such as heart disease, diabetes, autoimmune disease, and obesity. Even slight elevations in hs-CRP can signal that the immune system is under stress. It is a valuable marker for cardiovascular risk assessment and monitoring systemic inflammation.

FSH, LH, Oestradiol, and TSH
These hormones regulate reproductive function, thyroid activity, and metabolism. In women, FSH and LH control the menstrual cycle and ovulation. In men, they regulate sperm and testosterone production. Oestradiol is the primary form of oestrogen and affects bone, mood, and fertility. TSH controls thyroid hormone production and is the primary screening test for thyroid dysfunction. Imbalances in these hormones can lead to fatigue, irregular cycles, weight changes, or fertility issues.

Free Triiodothyronine (FT3)
FT3 is the active form of thyroid hormone and has a direct influence on metabolism, energy, and mood. It is often affected before TSH or FT4 in cases of early thyroid dysfunction or stress. Low FT3 can contribute to fatigue, weight gain, or cold intolerance even when other thyroid markers are normal, making it useful for a comprehensive thyroid assessment.

Albumin
Albumin is the most abundant protein in your bloodstream and is produced by the liver. It plays a key role in maintaining fluid balance and transporting hormones, vitamins, and medications. Low albumin levels may indicate liver disease, malnutrition, or chronic inflammation. It’s a reliable general health marker, especially for assessing systemic wellbeing and liver function.

Alanine Transferase (ALT) and Bilirubin
These are important indicators of liver function and liver cell integrity. ALT is an enzyme released into the bloodstream when liver cells are damaged. Bilirubin is a pigment formed when red blood cells are broken down and is processed by the liver. Elevations in either marker may suggest liver inflammation, bile duct problems, or haemolysis. Together, they help detect early signs of liver disease.